2024-01 Customer publication in bioRxiv: Dissecting the membrane association mechanism of aerolysin pore at femtomolar concentrations using water as a probe DOI: 10.1101/2024.01.18.576179
2023-11 Customer publication in Analytical Chemistry: Confirming Silent Translocation through Nanopores with Simultaneous Single-Molecule Fluorescence and Single-Channel Electrical Recordings DOI: doi.org/10.1021/acs.analchem.3c02329
2023-06 Customer publication in ACS Nano: Evaluation of Nanopore Sensor Design Using Electrical and Optical Analyses DOI: 10.1021/acsnano.3c02532
2023-05 Customer publication in SciAdv: Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation DOI: 10.1126/sciadv.adf4936
2023-05 Customer publication in Nature Communications: Structural mechanisms of TRPM7 activation and inhibition DOI: 10.1038/s41467-023-38362-3
2023-03 Customer publication in PNAS: Activation energy for pore opening in lipid membranes under an electric field DOI: 10.1073/pnas.2213112120
2022-12 Customer publication in Advances in Model Membrane Systems: Evaluation of Cell-Free Synthesized Human Channel Proteins for In Vitro Channel Research DOI: 10.3390/membranes13010048
2022-05 Customer publication in Communications Biology: Circularized fluorescent nanodiscs for probing protein–lipid interactions DOI: 10.1038/s42003-022-03443-4
2022-04 Customer publication in Nature Communications: A reversibly gated protein-transporting membrane channel made of DNA DOI: 10.1038/s41467-022-28522-2
2022-04 Customer publication in Nature Nanotechnology: Highly shape- and size-tunable membrane nanopores made with DNA DOI: doi:10.1038/s41565-022-01116-1
2022-04 Customer publication in Nature: Opening of glutamate receptor channel to subconductance levels DOI: 10.1038/s41586-022-04637-w
2022-04 Customer publication in Front. Bioeng. Biotechnol.: The Potential of Eukaryotic Cell-Free Systems as a Rapid Response to Novel Zoonotic Pathogens: Analysis of SARS-CoV-2 Viral Proteins DOI: 10.3389/fbioe.2022.896751
2022-03 Customer publication in CELL: Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors DOI: 10.1016/j.cell.2022.02.002
2022-03 Customer publication in Science Advances: An oomycete NLP cytolysin forms transient small pores in lipid membranes DOI: 10.1126/sciadv.abj9406
2022-03 Customer publication in JACS: Triggered Assembly of a DNA-Based Membrane Channel DOI: 10.1021/jacs.1c06598
2022-01 Customer publication in mBio: Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins DOI: 10.1128/mbio.03510-21
2021-12 Customer publication in Int J Mol Sci.: Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain DOI: 10.3390/ijms23010335
2021-12 Customer publication in Molecular Cell: Structure and desensitization of AMPA receptor complexes with type II TARP g5 and GSG1L DOI: 10.1016/j.molcel.2021.09.030
2021-10 Customer publication in Nature Communications: Programmable nano-reactors for stochastic sensing DOI: 10.1038/s41467-021-26054-9
2021-06 Customer publication in Chemical Science: Rapid and multiplex preparation of engineered Mycobacterium smegmatis porin A (MspA) nanopores for single molecule sensing and sequencing DOI: 10.1039/D1SC01399H
2021-02 Customer publication in Nat Commun.: Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM DOI: 10.1038/s41467-021-21141-3
2021-01 Customer publication in eLife: ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels DOI: 10.7554/eLife.64787
2021 Customer publication in CRSB: Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins DOI: 10.1016/j.crstbi.2021.02.001
2020-12 Customer publication in Nat Protoc.: Design, assembly, and characterization of membrane-spanning DNA nanopores DOI: 10.1038/s41596-020-0331-7
2020-12 Customer publication in SciAdv.: Aerolysin nanopores decode digital information stored in tailored macromolecular analytes DOI: 10.1126/sciadv.abc2661
2020-10 Publication in Methods in Molecular Biology: Electrophysiology on Channel-Forming Proteins in Artificial Lipid Bilayers: Next-Generation Instrumentation for Multiple Recordings in Parallel DOI: 10.1007/978-1-0716-0818-0_4
2020-08 Customer publication in SciAdv.: Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel DOI: 10.1126/sciadv.aba4996
2020-05 Customer publication in Sci Rep.: New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies DOI: 10.1038/s41598-020-65246-z
2020-05 Customer publication as preprint in ChemRxiv: Dynamic Interaction of Norfloxacin to Magnesium Monitored by Bacterial Outer Membrane Nanopores Preprint Server Chemrxiv
2020-02 Publication in Sci Rep.: Mammalian Cell-Free Protein Expression Promotes the Functional Characterization of the Tripartite Non-Hemolytic Enterotoxin From Bacillus Cereus DOI: 10.1038/s41598-020-59634-8
2020-02 Customer publication in Angew Chem Int Ed Engl.: Electrophysiological Characterization of Transport Across Outer-Membrane Channels From Gram-Negative Bacteria in Presence of Lipopolysaccharides DOI: 10.1002/anie.201913618
2020-02 Customer publication in Sci Adv.: Structure and Mechanism of Bactericidal Mammalian perforin-2, an Ancient Agent of Innate Immunity DOI: 10.1126/sciadv.aax8286
2020-02 Visit us at the 64th Annual Meeting of the Biophysical Society in San Diego
2019-11 Customer publication in Nature communications: Synthetic protein-conductive membrane nanopores built with DNA DOI: 10.1038/s41467-019-12639-y
2019-10 Publication in Langmuir: Activity of the Gramicidin A Ion Channel in a Lipid Membrane with Switchable Physical Properties DOI: 10.1021/acs.langmuir.9b02752
2019-08 Customer publication in Frontiers in Pharmacology: Functional Reconstitution of Membrane Proteins Derived From Eukaryotic Cell-Free Systems DOI: 10.3389/fphar.2019.00917
2019-07 Customer publication in Journal of Biological Chemistry: Arg-8 of yeast subunit e contributes to the stability of F-ATP synthase dimers and to the generation of the full-conductance mitochondrial megachannel. DOI: 10.1074/jbc.RA119.008775
2019-06 Customer publication in The European Physical Journal E:A comparison of ion channel current blockades caused by individual poly(ethylene glycol) molecules and polyoxometalate nanoclusters DOI: 10.1140/epje/i2019-11838-3
2019-04 Customer publication in PLOS Biology:Structure of the human ClC-1 chloride channel DOI: 10.1371/journal.pbio.3000218
2019-03 Customer publication in Angew Chem Int Ed Engl.: Small-Molecule Permeation across Membrane Channels: Chemical Modification to Quantify Transport across OmpF DOI: 10.1002/anie.201814489
2019-03 Customer publication in Anal. Bioanal. Chem.: Real-time monitoring beta-lactam/beta-lactamase inhibitor (BL/BLI) mixture towards the bacteria porin pathway at single molecule level DOI: 10.1007/s00216-019-01650-3
2019-03 Get a preview of the new MECAopto-inv!
2019-02 Customer publication in Cells: Purification of Functional Human TRP Channels Recombinantly Produced in Yeast DOI: 10.3390/cells8020148
2019-03 Customer publication in Angew Chem Int Ed Engl.: Small-Molecule Permeation across Membrane Channels: Chemical Modification to Quantify Transport across OmpF DOI: 10.1002/anie.201814489
2019-03 Customer publication in Anal Bioanal Chem.: Real-time monitoring (beta)-lactam/(beta)-lactamase inhibitor (BL/BLI) mixture towards the bacteria porin pathway at single molecule level DOI: 10.1007/s00216-019-01650-3
2019-03 Visit us at the 63th Annual Meeting of the Biophysical Society in Baltimore
Get a preview of the new MECAopto-inv!
2019-02 Customer publication in Cells: Purification of Functional Human TRP Channels Recombinantly Produced in Yeast DOI: 10.3390/cells8020148
2018-10 Customer publication in mBio: The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S DOI: 10.1128/mBio.00802-18
2018-06 Customer publication in Eur. Phys. J. E: Size-dependent interaction of a 3-arm star poly(ethylene glycol) with two biological nanopores DOI: 10.1140/epje/i2018-11687-6
2018-04 New application cases:
TOM-complex, Fusion of Brush Border Membrane Vesicles, and ion channel transfer from nanodiscs.
2018-03 Customer publication in ScienceAdvances: Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1 DOI:10.1126/sciadv.aaq0762
2018-03 Customer publication in Nature communications: Stability and dynamics of membrane-spanning DNA nanopores DOI:10.1038/ncomms14784
2018-03 Customer publication in ACS Nano: Defined Bilayer Interactions of DNA Nanopores Revealed with a Nuclease-Based Nanoprobe Strategy DOI:10.1021/acsnano.7b07835
2018-02 Customer publication in Eng Life Sci: Cell-free production of pore forming toxins: Functional analysis of thermostable direct hemolysin from Vibrio parahaemolyticus DOI:10.1002/elsc.201600259
2018-02 Visit us at the 62th Annual Meeting of the Biophysical Society in San Francisco
2018-01 Customer publication in Nature: Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties DOI:10.1038/nature25481
2017-10 Temperature Control on the MECA chip Temperature dependence of a-hemolysin and Gramicidin A.
2017-10 Customer publication in Protein Engineering. Methods in Molecular Biology, vol 1685.: Functional Analysis of Membrane Proteins Produced by Cell-Free Translation DOI:10.1007/978-1-4939-7366-8_10
2017-09 Customer publication in eLife: Molecular determinants of permeation in a fluoride-specific ion channel. DOI:10.7554/eLife.31259
2017-09 Customer publication in Scientific Reports: High-yield production of "difficult-to-express" proteins in a continuous exchange cell-free system based on CHO cell lysates. DOI:10.1038/s41598-017-12188-8
2017-07 Visit us at the 648. WE-Heraeus-Seminar in Bremen, Germany
2017-03 Customer publication in Nature communications: Stability and dynamics of membrane-spanning DNA nanopores DOI:10.1038/ncomms14784
2017-02 Customer publication in Scientific Reports: Engineering a pH responsive pore forming protein DOI:10.1038/srep42231
2017-02 Visit us at the 61th Annual Meeting of the Biophysical Society in New Orleans
2016-12 Customer publication in Insect Molecular Biology: Validation of ADAM10 metalloprotease as a Bacillus thuringiensis Cry3Aa toxin functional receptor in Colorado potato beetle (Leptinotarsa decemlineata)
DOI:10.1111/imb.12285
2016-12 Customer publication in Biophysical Journal: Alamethicin Supramolecular Organization in Lipid Membranes from 19F Solid-State NMR
DOI:10.1016/j.bpj.2016.09.048
2016-09 Visit us at the Annual Meeting of the German Biophysical Society 2016 in Erlangen, Germany
2016-08 First time on the MECA chip: Functional membranes from synthetic triblock copolymers
2016-07 First customer publication featuring the Orbit mini: Mechanistic signs of double-barreled structure in a fluoride ion channel
DOI: 10.7554/eLife.18767
2016-07 Newcomer in our channel zoo: VDAC.
2016-04 Visit us at the Joint Meeting of the Membrane Sections of the French and German Biophysical Societies in Bad Herrenalb, Germany
2016-01 Customer publication in Nature Nanotech: A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane
DOI:10.1038/nnano.2015.279
2016-01 Don't miss Ionera's Technology featured in a WEBINAR on 27.01.2016: Orbit mini and Orbit 16. Instant bilayers - just add protein.
2016-01 Visit us at the 60th Annual Meeting of the Biophysical Society in Los Angeles
2015-07 Visit us at the 10th European Biophysics Congress in Dresden, Germany
2015-06 Customer publication in ACS Nano: High-Resolution Size-Discrimination of Single Non-Ionic Synthetic Polymers with a Highly Charged Biological Nanopore.
See press release here
DOI:10.1021/acsnano.5b02096
2015-06 Ionera wins the ACHEMA Start-Up Award 2015
Press release ACHEMA
Press release University of Freiburg
2015-05 Visit us at the ACHEMA at the booth of the winners of the ACHEMA Start-Up Award 2015
2015-04 Visit us at the 3rd Prato Conference On Pore Forming Proteins in Prato, Italy
2015-02 Ionera released the MECA4 - the world's smallest 4 channel bilayer measurement chamber at the 59th Annual Meeting of the Biophysical Society in Baltimore 2015
2014-10 Customer publication in ACS Nano: Bilayer-Spanning DNA Nanopores with Voltage-Switching between Open and Closed State
DOI:10.1021/nn5039433
2014-09 Customer publication in Nature: Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG DOI:10.1038/nature13768
Read more at UCL News
2014-08 Publication on the Automated Formation of Lipid Membrane Microarrays for Ionic Single-Molecule Sensing with Protein Nanopores
DOI: 10.1002/smll.201402016
2014-08 Joint publication on the Generation of chip based microelectrochemical cell arrays for long-term and high-resolution recording of ionic currents through ion channel proteins
DOI: 10.1016/j.snb.2014.08.001
2014-07 Ionera's MECA Technology in live experiments at the International workshop on high-throughput bilayer ephys in Munich, July 21/22, 2014.
2014-04 Ionera's MECA Technology is featured in Chemie Plus.
2014-01 Visit us at the 58th annual meeting of the Biophysical Society in San Francisco 2014.
2013-06 Ionera is one of the finalists of the bwcon Cyberone Hightech Award 2013. Read more....
2013-03 Ionera has been awarded the Innovationspreis Freiburg. Read more...
2013-03 Ionera wins at the Science4Life Venture Cup 2013. Read more....
2012-11 Ionera's MECA bilayer array and Nanion's Orbit 16 enable the functional analysis of synthetic DNA-Origami nanopores